Abstract: Objective To clarify the pathogenic spectrum of respiratory tract infection in a hospital in Beijing from 2017 to 2020, and to provide pathogenic evidence for the prevention and treatment of respiratory tract infection. Methods The clinical inspection data of adult patients with respiratory tract infection in a hospital in Beijing from January 2017 to December 2020 were analyzed, and the distribution characteristics of pathogenic spectrum were analyzed. Results There were 8 026 patients with respiratory tract infection, including 5 200 males and 2 826 females, with an average age of （49.12±8.87） years.A total of 9 565 pathogens were detected, including 5 167 strains of bacteria （54.02%）, 1 435 strains of fungi （15.00%） and 2 963 strains of virus （30.98%）.There were statistically significant differences in pathogen distribution among different years, sample sources, gender, age and season （all P<0.01）.Conclusion The pathogenic spectrum of respiratory tract infection cases in a hospital in Beijing is mostly bacteria, followed by virus and fungi, with obvious age, gender, and seasonal characteristics. It is suggested to take effective preventive measures according to the above characteristics to reduce the risk of respiratory tract infection.

Key words: Respiratory tract infection, Pathogenic spectrum, Gram-positive bacteria, Gram-negative bacteria, Virus, Fungi