Abstract: Objective To systematically evaluate the impact of psychological intervention on negative emotions and quality of life in patients with gastrointestinal malignant tumors at home and abroad.Methods Papers published in the databases of Wanfang, WIP Chinese Sci-tech, China How Net, China Biomedical Literature Database, European PMC, Pubmed, EMbase and Web of science and Cochrane Central from January 2009 to now on the impact of psychological intervention on negative emotions and quality of life of patients with gastrointestinal malignant tumors were retrieved and screened, and the quality of literature was evaluated to conduct a meta-analysis.Results Nine literatures were extracted and they were all with high quality. A total of 896 subjects were enrolled, including 398 in the observation group and 398 in the control group. There were no significant differences in the heterogeneity test of SAS, SDS, EORTC QLQ-C30 and SF-36 scores after nursing （P > 0.05 for all）. Meta-analysis showed that the SAS scores of the observation group were significantly decreased （WMD=-20.63, 95% CI： -34.82 - -14.57, P<0.01）, SDS scores decreased significantly （WMD=-7.89, 95% CI：-10.02 - -5.63, P<0.01）, EORTC QLQ-C30 scores increased significantly （WMD=5.67, 95% CI： 2.18-7.12, P<0.01）, and SF-36 scores increased significantly （WMD = 3.63, 95% CI： 0.97-5.88, P<0.01）.No significant risk of bias was found among the literatures.Conclusion Psychological intervention can significantly reduce anxiety and depression in patients with gastrointestinal malignant tumors, and improve their quality of life.

Key words: Psychological intervention, Malignant tumor, Negative emotion, Quality of life