Abstract: Objective To analyze the characteristics and treatment costs of inpatients with upper gastrointestinal hemorrhage （UGIB）, so as to provide basis for formulating prevention and control policies and measures, improving treatment methods, improving the prognosis of patients and guiding the medical system to coordinate the disease cost. Methods All the newly diagnosed UGIB inpatients in a hospital in Chengdu City in 2019 were searched from the hospital information management system, and the medical records and treatment costs were analyzed. Results A total of 308 UGIB inpatients were included. Among them, 144 cases were aged from 24 to 59 years （young and middle-aged group）, with an average age of （42.05 ± 7.54） years,and male accounted for 70.14%. 164 cases were aged from 60 to 88 years （elderly group）, with an average age of （73.54 ± 6.05） years,and male accounted for 82.83%. There were statistically significant differences between the two groups in the history of NSAIDs, hypertension, diabetes, coronary heart disease, stroke, chronic obstructive pulmonary disease, and more than two complications （P<0.05 or P<0.01）. The main clinical manifestations of UGIB patients were melena （57.14%）, epigastric pain （35.39%） and hematemesis （27.60%）. The main causes of bleeding were duodenal ulcer （34.74%）, gastric ulcer （20.78%）, gastroduodenitis （11.36%）. The proportion of epigastric pain in the young and middle-aged group was higher than the elderly group, and the peripheral circulation disorder was lower than the elderly group （all P<0.01）. The proportion of duodenal ulcer, esophageal and gastric varices in the young and middle-aged group was higher than the elderly group, and the proportion of gastric ulcer, compound ulcer and gastric cancer was lower than the elderly group （P<0.01 or P<0.05）. The median length of stay was 12.40 （6.16, 25.51） days in the young and middle-aged group, and 16.21 （6.35, 25.54） days in the elderly group. The average treatment costs was （12 783.6 ± 1 743.1） yuan in the young and middle-aged group, and （21 785.6 ± 2 762.3） in the elderly group. The cost of Western medicine, Chinese patent medicine, blood transfusion, examination, operation, total cost and length of stay in the elderly group were higher than the young and middle-aged group （P<0.05 or P<0.01）. Conclusion UGIB inpatients are mainly male. The clinical manifestations and hemorrhagic causes of UGIB patients in different age groups are different. The treatment time and cost of elderly UGIB patients are significantly higher than that of young and middle-aged groups.

Key words: Upper gastrointestinal hemorrhage, Young and middle-aged, Elderly, Etiology, Treatment cost