Abstract: Objective To investigate the status of Helicobacter pylori （Hp） infection in the physical examination population, clarify its influencing factors, provide reference information for clinical prevention, treatment of Hp infection.Methods A simple random sampling method was used to sample the physical examination population in the medical examination center of a hospital in Beijing from June2018to May2019. Questionnaire survey, urea [, blood biochemical index detection were conducted among the selected population. Descriptive epidemiological analysis was used to analyze the Hp infection in this population, the influencing factors were analyzed by univariate, multivariate analysis.Results A total of1,058physical examination populations were surveyed. The male-to-female ratio in the survey population was1∶0.9. The age group was mainly30-59years old, accounting for45.94%, the education level was mainly high school/ secondary specialized school, accounting for38.00%. Among them, 338cases of Hp positive were detected, the positive rate was31.95%. Multivariate logistic regression analysis showed that the older the age （OR=3.097）, Hcy abnormality （OR=3.662）, the drinking habit （OR=4.484）, the greater the risk of Hp positive;and the higher the level of Hp knowledge （OR=0.163）, the lower the risk of Hp positive.Conclusion The Hp infection rate in the physical examination population is relatively high. Age, drinking, lack of knowledge about Hp, Hcy abnormality, etc. are related to Hp infection. Corresponding protective measures should be formulated according to the characteristics of human infection to reduce the risk of Hp infection

Key words: Helicobacter pylori, Urea[¹³C] powder breath test, Influencing factor