Abstract: Objective To explore the correlation between hemoglobin glycation index （HGI） and chronic complications of diabetes mellitus in patients with type 2 diabetes （T2DM）. Methods Cluster random sampling method was used to select 12 from 34 villages and towns in Changshu City, and T2DM patients registered in the selected villages and towns and included in the management of National Basic Public Health Services were selected as the research objects. The participants were divided into low HGI group, middle HGI group and high HGI group according to the HGI value. The correlation of HGI and the risk of chronic complications of diabetes mellitus was estimated. Univariate analysis was performed by Chi-square test and multivariate analysis by multivariate Logistic regression model. Results A total of 10 246 T2DM patients （4 157 males and 6 089 females） were included in the survey, with 66.41% aged over 60 years old. Univariate analysis showed that HGI was significantly associated with chronic complications of diabetes mellitus and diabetic retinopathy （both P<0.01）. But no significant associations of HGI with diabetic nephropathy, diabetic neuropathy and diabetic foot were found （all P>0.05）. After adjusting for age, sex, education, smoking history, obesity, dyslipidemia, diabetes duration and family history of diabetes, Logistic regression analysis showed that high HGI group had a significantly increased risk of chronic complications of diabetes mellitus （ OR=1.240, 95% CI： 1.091-1.409） and diabetic retinopathy （OR=1.240, 95% CI： 1.070-1.437） compared with low HGI group. Conclusion The patients with high HGI may be more likely to develop chronic complications of diabetes mellitus, especially diabetic retinopathy.

Key words: Type 2 diabetes, Glycosylated hemoglobin, Hemoglobin glycation index, Complication