Abstract: Objective To investigate the status and influencing factors of osteoporosis in patients with type 2 diabetes mellitus （T2DM） in Changping District, Beijing. Methods In October 2020, T2DM patients were recruited as survey subjects in 16 community service centers in Changping District, Beijing. Data collection, physical examination, blood biochemical index detection, and bone mineral density detection were performed on T2DM patients who met the research conditions. The descriptive analysis method was used to analyze the incidence of osteoporosis in T2DM patients, and univariate and multivariate analysis methods were used to analyze the influencing factors of osteoporosis in T2DM patients. Results A total of 2 126 T2DM patients with valid data were recruited in this study, aged 22-76 years old, and the course of disease was mainly 1-9 years, accounting for 68.53%. The incidence of osteoporosis in 2 126 T2DM patients was 10.11%. The multivariate Logistic regression model showed that age （OR=2.512）, course of disease （OR=1.956）, body mass index （BMI） （OR=0.399）, smoking （OR=2.895）, physical exercise （OR=0.459）, blood glucose monitoring （OR=2.533）, glycosylated hemoglobin （HbA1c） （OR=3.517）, parathyroid hormone （PTH） （OR=2.777）, alkaline phosphatase （ALP） （OR=3.452）, 25-hydroxyvitamin D [25（OH）D] （OR=1.982） were influencing factors of osteoporosis in T2DM patients. Conclusion T2DM patients in Changping District of Beijing have a higher risk of osteoporosis, and the influencing factors include age, course of disease, BMI, smoking, physical exercise, blood glucose monitoring, HbA1c, PTH, ALP, and 25（OH）D levels. Improving the clinical prevention and treatment system will help reduce the risk of osteoporosis in T2DM patients.

Key words: Osteoporosis, Type 2 diabetes mellitus, Bone mineral density, Influencing factor