Abstract: Objective To investigate the nutritional status and its influencing factors of newly diagnosed patients with esophageal cancer, to provide a reference for the formulation of nutritional support interventions and to improve patient outcomes. Methods ?The nutritional status and its influencing factors of newly diagnosed patients with esophageal cancer at the First Affiliated Hospital of Xinxiang Medical College were investigated from January 2020 to December 2021 . The nutritional status was evaluated by using the Mini-Nutritional Assessment form （MNA）, and the symptoms were evaluated by using the Chinese version of the Memorial Symptom Assessment Scale （MSAS）. The nutritional risk of newly diagnosed patients with esophageal cancer was analyzed using a descriptive analysis, with a univariate and multivariate analysis of the influencing factors of nutritional status. Results There were 541 newly diagnosed patients with esophageal cancer, of which 196 （36.23%） had normal nutrition, 236 （43.62%） had risk of malnutrition, and 109 （20.15%） had malnutrition. In the MSAS of newly diagnosed patients with esophageal cancer, the scores of physiological symptoms, psychological symptoms, total distress index, and total MSAS were （2.03±0.49）, （1.02±0.25）, （1.16±0.31）, and （1.28±0.39） respectively. Multivariate Logistic regression analysis indicated age （OR=1.412）, dietary habits （OR=2.768）, segmentation of esophageal cancer （OR=3.658）, stage of esophageal cancer （OR=4.586）, physiological symptoms （OR=1.775）, psychological symptoms （OR=2.171）, total distress index （OR=2.712）,and total score of MSAS （OR=1.119） were the factors affecting the nutritional status of newly diagnosed patients with esophageal cancer. Conclusions Most newly diagnosed patients with esophageal cancer in the Weihui region are at risk of malnutrition. Therefore, a comprehensive assessment should be carried out based on the patient's symptoms, and individualized and efficient intervention measures should be taken in combination with other factors affecting the nutritional status to improve the quality of life of the patient.

Key words: Esophageal cancer, Symptom, Malnutrition, Influencing factor