Abstract: Objective To analyze the status and influencing factors of enteral nutrition feeding intolerance in patients with sepsis, and to provide a reference for effective intervention measures. Methods Patients with sepsis who received enteral nutrition at the First Affiliated Hospital of Shandong First Medical University from January 2019 to December 2021 were selected as subjects. Medical staff monitored whether patients experienced feeding intolerance during enteral nutrition, and collected patients' basic information, disease status, and drug use. The descriptive analysis method was used to analyze the occurrence of enteral nutrition feeding intolerance, and univariate and multivariate analysis methods were used to analyze the influencing factors of enteral nutrition feeding intolerance in patients with sepsis. Results A total of 526 subjects were obtained, and with 218 cases of enteral nutrition feeding intolerance, the incidence rate was 41.44%. Most intolerances occurred within 3-4 days of enteral nutrition, accounting for 44.50%, and the duration of intolerance was mostly 1 day, accounting for 46.33%. The main manifestations were diarrhea （62.39%）, abdominal distension （40.83%）, and gastric retention （15.60%）. Multivariate Logistic regression analysis showed that blood glucose （OR=2.021）, serum albumin （OR=0.209）, use of sedatives/analgesics （OR=1.335）, use of acid suppressor （OR=1.530）, use of potassium preparations （OR=1.677）, use of probiotics （OR=0.640）, type of antibiotic use （OR=1.471）, and mechanical ventilation （OR=3.009） were the influencing factors of enteral nutrition feeding intolerance in patients with sepsis. Conclusions The incidence of enteral nutrition feeding intolerance in patients with sepsis is high, and the influencing factors are complex and diverse. Attention should be paid to the use of sedatives/analgesics, acid suppressor, potassium preparations, probiotics, antibiotics, and mechanical ventilation. Blood glucose and serum albumin should be monitored. Appropriate enteral nutrition catheterization and nutritional preparations should be selected according to individual conditions, and inspection and observation should be strengthened during enteral nutrition to prevent and reduce feeding intolerance.

Key words: Sepsis, Enteral nutrition, Feeding intolerance, Influencing factor