Abstract: Objective To investigate the influencing factors of coronary plaque stability in patients with coronary heart disease in Beijing. Methods The study subjects were patients with coronary heart disease admitted to Beijing Shijitan Hospital, Rocket Force Characteristic Medical Center, and Beijing Sijiqing Hospital from January 2019 to December 2021. According to the results of optical coherence tomography （OCT） examination, patients were divided into plaque unstable group and plaque stable group. Univariate and multivariate analysis methods were used to explore the influencing factors of coronary plaque stability in patients with coronary heart disease. Results A total of 2 116 patients with coronary heart disease were included, including 1 388 males and 728 females; aged 39-85 years, with an average age of （65.97 ± 9.16） years. There were 1 429 patients ≥ 60 years old and 687 patients<60 years old. The duration of coronary heart disease was 6-73 months, with a median duration of 42 months. The results of multivariate logistic regression analysis showed that age （OR=7.178）, smoking （OR=4.162）, blood uric acid level （OR=3.850）, LDL-C （OR=3.228）, C-reactive protein （OR=4.577）, fibrinogen （OR=5.083）, homocysteine （OR=4.112）, cystatin C level （OR=3.124）, secondary preventive drug use （OR=0.215）, low-fat diet intervention （OR=0.274）, weekly exercise<3 times （OR=3.983）, and sleep time<6 h （OR=3.838） were influencing factors for coronary plaque stability in patients with coronary heart disease. Conclusion The coronary plaque stability in patients with coronary heart disease is affected by their age, smoking, blood uric acid level, secondary preventive drug use, low-fat diet intervention, exercise, sleep, plasma low-density lipoprotein, C-reactive protein, fibrinogen, homocysteine, and cystatin C levels.

Key words: Coronary heart disease, Coronary artery, Plaque, Stability, Influencing factor