Abstract: Objective To investigate the daily life impact and its change of the COVID-19 on urban and rural adult residents in the context of epidemic prevention and control of Class-A infectious diseases. Methods In March 2020 and March 2021, convenience sampling was used to investigate the basic information about respondents, the surrounding epidemic situation, and the impact on their daily life. Chi-square test and multivariate logistic regression analysis were used to analyze the impact of epidemic prevention and control on daily life through a 1∶1 matching of the influencing factors. Results In 2020 and 2021, 92.5% （1 785/1 929） and 69.4% （1 532/2 209） of residents, respectively, reported that their daily lives were affected by the epidemic, with 43.5% （839/1 929） and 24.4% （539/2 209） being greatly affected, respectively. Multivariate analysis found that in 2020, medical impact （high OR=8.790, medium OR=3.408, small OR=1.547）, graduate education level （OR=1.679）, Hubei residents （OR=1.590）, surrounding epidemic situation （severe OR=1.468, mild OR=1.282）, not working at the time of investigation （OR=1.427）, and poor health condition （OR=1.360） were the influencing factors of residents’ daily life greatly affected by the epidemic. In 2021, medical impact （moderate or above OR=7.910, small OR=1.817）, historically high-risk areas （OR=1.465）, and unmarried/divorced/widowed （OR=1.316） were the influencing factors of residents’ daily life greatly affected by the epidemic. After sample matching, it was found that the daily life impact of the epidemic on residents in the regular epidemic prevention and control period was significantly reduced （P<0.01）. Conclusion In the context of epidemic prevention and control of Class-A infectious diseases, the daily life of Chinese residents was greatly affected by the epidemic in March 2020, and the impact of the epidemic was significantly weakened in March 2021.

Key words: COVID-19, Adult residents, Daily life impact, Influencing factor