Abstract: Objective To investigate the occurrence of wound infection and the characteristics of pathogenic bacteria in burn patients, and analyze the relevant factors affecting wound infection. Methods The hospitalized burn patients admitted to two Grade A hospitals in Wuhan from January 2019 to December 2021 were selected as the subjects. Automatic microbial analysis was used to detect pathogenic bacteria in patients with wound infection, the self-made information collection form was used to collect basic information, burn condition, combined chronic diseases, and treatment of burn patients. The descriptive analysis method was used to analyze the wound infection of burn patients, and univariate and multivariate analysis methods were used to analyze the influencing factors of wound infection. Results In this study, a total of 1 532 burn patients were collected, and 287 cases developed wound infection, with an infection rate of 18.73%. A total of 369 strains of pathogenic bacteria were detected in 287 infected patients, including 248 strains of Gram-negative bacteria （67.21%）, the top three strains were Pseudomonas aeruginosa （89 strains, 24.12%）, Acinetobacter baumannii （50 strains, 13.55%）, and Klebsiella pneumoniae （32 strains, 8.67%）; There were 121 strains of Gram-positive bacteria （32.79%）, the top three strains were Staphylococcus aureus （53 strains, 14.36%）, Staphylococcus epidermidis （43 strains, 11.65%）, and Enterococcus faecalis （9 strains, 2.44%）. The results of multivariate logistic regression analysis showed that the burn area （10%-30% OR=1.932, 31%-49% OR=4.352, ≥50% OR=9.655）, burn depth （depth Ⅱ degree OR=2.048, Ⅲ degree OR=4.170）, inhalation injury （OR=2.542）, early shock （OR=4.593）, diabetes mellitus （OR=7.708）, ≥3 kinds of antibiotics were used （OR=4.705）, length of stay （15-29 days OR=9.289, ≥30 days OR=9.787）, stay in ICU （OR=2.770） were the influencing factors of wound infection in burn patients. Conclusions The wound infection of burn patients is closely related to the burn area, burn depth, and other factors, and the pathogenic bacteria are mainly Gram-negative bacteria. Targeted measures should be taken during hospitalization to reduce the risk of infection and prevent wound infection.

Key words: Burn, Wound infection, Pathogenic bacteria, Influencing factor