Abstract: Objective To investigate and analyze the medication compliance of patients with type 2 diabetes mellitus combined with other chronic diseases, and explore the possible influencing factors of medication compliance. Methods Patients with type 2 diabetes mellitus who were admitted to the General Hospital of Eastern Theater Command, Community Health Service Center of Qiaolin Street, Pukou District, Nanjing City, and Nanjing Jiangdong Community Health Service Center from June 2021 to June 2023 were selected by convenient sampling method to investigate their medication compliance and complications of other chronic diseases. The influencing factors of medication compliance in patients with type 2 diabetes mellitus combined with other chronic diseases were analyzed by univariate and multivariate analysis methods. Results A total of 1 135 patients with type 2 diabetes mellitus were investigated in this study, among which 453 patients （39.91%） had poor medication compliance. Among the 1 135 patients, 874 were combined with other chronic diseases, and the proportion of poor medication compliance was 44.97% （393/874）. Multivariate logistic regression analysis showed that education level of junior high school or below （OR=5.749）, combined with cardiovascular and cerebrovascular diseases or chronic respiratory diseases （OR=2.482, 3.313）, types of medication ≥3 （OR=3.377）, knowledge of medication （OR=0.391, 0.328）, and without phone or face-to-face follow-up within the past 6 months （OR=7.128） were influencing factors for poor medication compliance in patients with type 2 diabetes mellitus combined with other chronic diseases. Conclusions The overall medication compliance of patients with type 2 diabetes mellitus combined with other chronic diseases is poor and needs to be improved. The improvement of intervention measures such as disease knowledge popularization, medication knowledge education, and simplified drug therapy should be carried out according to the relevant factors affecting the medication compliance of this population.

Key words: Type 2 diabetes mellitus, Chronic disease, Medication compliance, Influencing factor