岳池县中老年女性骨代谢指标与骨质疏松的相关性研究

doi:10.12183/j.scjpm.2021.0985

摘要/Abstract

摘要： 目的分析中老年女性骨质疏松发生情况,并探讨骨代谢指标与骨质疏松的相关性,为中老年女性骨质疏松的防治工作提供参考资料。方法以2020年1—12月岳池县某医院进行健康体检的≥45岁中老年女性作为研究对象,进行骨密度、血清中骨钙素（OC）、β胶原特殊序列（βCTX）、骨碱性磷酸酶（BALP）、25-羟基维生素D [25-（OH）D]水平检测,采用描述性分析方法对该人群骨质情况进行分析,在校正年龄、体质指数（BMI）基础上采用多因素Logistic回归分析方法对骨代谢指标水平对骨质疏松影响情况进行分析。结果共对1 124名中老年女性进行调查,年龄45~78岁,平均（61.4±5.8）岁。共检出骨质疏松558例,发生率为49.6%。不同年龄、BMI的中老年女性骨量情况差异均有统计学意义（P<0.05或P<0.01）。不同居住地、年龄、BMI、绝经情况和骨量情况的中老年女性骨代谢指标差异均有统计学意义（均P<0.01）。随着年龄增长,25-（OH）D水平呈下降趋势,OC、BALP水平在55~64岁明显升高后呈逐渐下降趋势,βCTX呈升高趋势。多因素Logistic回归分析结果显示,OC（OR=0.537）、BALP（OR=0.791）、25-（OH）D（OR=0.674）水平越高,发生骨质疏松的可能性越低;βCTX水平越高（OR=1.919）,发生骨质疏松的可能性越大。结论岳池县≥45岁中老年女性骨质疏松发生率较高,骨代谢指标OC、βCTX、BALP、25-（OH）D能够有效反映骨代谢活动,且与骨质疏松发生情况密切相关,监测骨代谢指标可以及早发现骨代谢异常,有利于及早预防和发现骨质疏松症。

关键词: 骨质疏松, 中老年, 女性, 骨代谢, 骨密度

Abstract: Objective To analyze the occurrence of osteoporosis in middle-aged and elderly women, and to explore the correlation between bone metabolic indexes and osteoporosis, so as to provide reference for the prevention and control of osteoporosis in middle-aged and elderly women. Methods Taking the middle-aged and elderly women ≥ 45 years old who underwent physical examination in a hospital of Yuechi County from January to December 2020 as the research object, the bone mineral density, serum osteocalcin （OC） and β collagen specific sequence （βCTX）, bone alkaline phosphatase （BALP） and 25-hydroxyvitamin D [25-（OH）D] were detected. The bone condition of the population was analyzed by descriptive analysis. On the basis of adjusting age and BMI, the impact of bone metabolic index on osteoporosis was analyzed by multivariate Logistic regression analysis. Results A total of 1 124 middle-aged and elderly women were investigated, aged 45-78 years, with an average of （61.4 ± 5.8） years. Among them, 558 cases of osteoporosis were detected, and the incidence rate was 49.6%. There were statistically significant differences in bone mass among middle-aged and elderly women with different ages and body mass index （BMI）（P<0.05 or P<0.01）. There were statistically significant differences in bone metabolic indexes among middle-aged and elderly women with different residence, age, BMI, menopausal status and bone mass （all P<0.01）. With age, the level of 25-（OH）D decreased, the levels of OC and BALP increased significantly from 55 to 64 years old and then decreased gradually, and βCTX showed an upward trend. Multivariate Logistic regression analysis showed that the higher the level of OC （OR=0.537）, BALP （OR=0.791）, and 25-（OH）D （OR=0.674）, the lower the probability of osteoporosis. The higher the level of βCTX （OR=1.919）, the greater the possibility of osteoporosis. Conclusion The incidence of osteoporosis in middle-aged and elderly women ≥45 years old in Yuechi County is high. Bone metabolic indexes such as OC, βCTX, BALP, and 25-（OH）D can effectively reflect bone metabolism, and have a significant correlation with osteoporosis. Monitoring bone metabolic indexes may lead to early detection of bone metabolism abnormalities, which is conducive to the early prevention and detection of osteoporosis.

Key words: Osteoporosis, Middle-aged and elderly, Women, Bone metabolism, Bone mineral density

中图分类号:

R580

杜超, 周维天, 夏伟. 岳池县中老年女性骨代谢指标与骨质疏松的相关性研究[J]. 华南预防医学, 2021, 47(8): 985-988.

DU Chao, ZHOU Wei-tian, XIA Wei. Correlation between bone metabolic indexes and osteoporosis among middle-aged and elderly women in Yuechi County[J]. South China Journal of Preventive Medicine, 2021, 47(8): 985-988.

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