Abstract: Objective To analyze the temporal and spatial distribution of primary and secondary（P&S） syphilis in different periods in Jingzhou City, so as to provide reference for rational allocation of health resources. Methods The data of P&S syphilis cases in Jingzhou City from 2011 to 2019 were collected. According to the incidence rate, the epidemic stages of P&S syphilis in Jingzhou City were divided into three periods： 2011-2013 （high）, 2014-2016 （middle）, 2017-2019 （low）. The temporal and spatial trends of P&S syphilis were analyzed by trend surface analysis, spatial autocorrelation analysis and spatio-temporal scanning. Results From 2011 to 2019, 4 715 cases of P&S syphilis were reported in Jingzhou City, with an average annual incidence rate of 9.19/100,000, and the incidence rate was decreasing （P<0.01）. Trend surface analysis showed that the high incidence area of P&S syphilis in Jingzhou City gradually shifted from Northwest （2011-2013） to Central （2017-2019）. The global spatial autocorrelation analysis showed that the incidence rate of P&S syphilis in Jingzhou City was positively correlated in 2011-2013 and 2014-2016, and there was spatial clustering （Moran 's I=0.333 6, 0.210 5, both P<0.01）. Local spatial autocorrelation analysis showed that the P&S syphilis high-value clustering areas mainly concentrated in some towns of Gongan County, Jingzhou District, Shashi District and Jiangling County in 2011-2013 （P<0.05）, mainly concentrated in some towns of Jingzhou District, Shashi District and Jianli County in 2014-2016 （P < 0.05）, and mainly concentrated in some towns of Jianli County and Shashi District in 2017-2019 （P < 0.05）. Spatio-temporal scanning showed that main clustering area was in Gongan County and Jiangling County, with a total of 24 townships （streets）, the clustering time was from April 11, 2011 to August 15, 2011 （RR=4.14, LLR=93.55）. Conclusion During the three periods, there is spatial aggregation of P&S syphilis in Jingzhou City, and the high incidence area is gradually reduced. From 2017 to 2019, some towns in Jianli County and Shashi District are high incidence areas, and prevention and control of the area should be strengthened.

Key words: Primary syphilis, Secondary syphilis, Incidence rate, Spatial characteristics