Abstract: Objective To understand the incidence and risk factors of diabetic nephropathy （DN） in type 2 diabetes mellitus （T2DM） patients in Yunnan Province, and to provide scientific basis for the prevention and treatment of DN. Methods Using random cluster sampling method, community T2DM patients （aged over 18 years old and all living in Yunnan for more than 1 year） in Yunnan were selected as the research objects. Questionnaire survey, physical examination and laboratory test were conducted from January to March in 2019 to calculate the incidence of DN. Chi-square test and multivariate unconditional Logistic regression analysis were used to analyze the influencing factors of DN. Results A total of 5 122 patients with T2DM were investigated, including 2 317 males （45.24%） and 2 805 females （54.76%）. The average age was （56.28±19.03） years old, and 2 649 patients （51.72%） were 45 - 59 years old; 3 834 cases （74.85%） were in marriage; 2 190 cases （42.76%） lived in urban areas, and 2 932 cases （57.24%） lived in rural areas; The education level of 2 051 cases （40.04%） was junior high school. There were 1 462 cases of DN, and the incidence rate was 28.54%. Multivariate unconditional Logistic regression analysis showed that age 60-90 years old （OR=1.994, 95%CI： 1.409-2.821）, duration of T2DM 11-15 years （OR=1.530, 95%CI： 1.207-1.939）, smoking （OR=1.441, 95%CI： 1.203-1.726）, meat intake frequency > 1 time/week （OR=1.347, 95%CI： 1.134-1.599）, obesity （OR=1.678, 95%CI： 1.338-2.104）, hypertension （OR=2.086, 95%CI： 1.367-3.182）, high levels of total cholesterol （TC） （OR=2.070, 95%CI： 1.842-2.327）, and low levels of high-density lipoprotein cholesterol （HDL-C） （OR=1.799, 95%CI： 1.550-2.089） were risk factors for DN in T2DM patients in Yunnan, while participation in physical exercise （OR=0.613, 95%CI： 0.426-0.883） and glycated hemoglobin （HbA1c） compliance （OR=0.573, 95%CI： 0.413-0.794） were protective factors. Conclusion The incidence of DN in patients with T2DM in Yunnan is high. Older age, longer duration of T2DM, smoking, frequency of meat intake, physical exercise, hypertension, HbA1c compliance and BMI, TC, HDL-C are the main influencing factors of DN in patients with T2DM in this area.

Key words: Type 2 diabetes mellitus, Diabetic nephropathy, Incidence, Risk factor