Abstract: Objective To investigate the anxiety and depression of adolescents during home quarantine of COVID-19, and explore their influencing factors. Methods Using a cluster sampling method, a questionnaire survey of anxiety and depression was conducted among students in 6 middle schools in Shandong, Shannxi, Liaoning, Henan and Fujian Province based on the class. Chi-square test and multivariate Logistic regression were used to analyze the related factors that affect adolescents’ anxiety and depression. Results A total of 11 430 adolescents were included as the research subjects, of which 5 818 were boys （50.9%） and 5 612 were girls （49.1%）;5 503 （48.1%） in rural areas, 5 927 （51.9%） in urban areas; 238 （2.1%） had found COVID-19 cases in their communities or villages, 9 703 （84.9%） were absent, and 1 489 （13.0%） were unknown. A total of 2 706 cases （23.6%） with anxiety and 4 334 cases （37.9%） with depression were detected. Multivariate Logistic regression showed that adolescents who were female （OR=1.673）, older （OR=1.271,1.460）, lower class ranking （OR=1.193,1.575,1.699）, had COVID-19 cases in or unknown their communities or villages （OR=2.320,2.197）, lived in Shandong Province （OR=1.806）, Fujian Province （OR=2.036）, Henan Province （OR=2.406）, Shaanxi Province （OR=1.575） were more likely to have anxiety. Adolescents who were female （OR=1.577）, older （OR=1.306,1.545）, lower class ranking （OR=1.157,1.384,1.527）, had COVID-19 cases or unknown in their communities or villages （OR=2.492,2.329）, lived in Shandong Province （OR=1.876）, Fujian Province （OR=2.335）, Henan Province （OR=2.413）, Shaanxi Province （OR=1.462） were at higher risk of depression. Conclusion During the home quarantine, the detection rate of anxiety and depression among adolescents were relatively high. The education department should conduct mental health education for adolescents in a timely manner.

Key words: COVID-19, Adolescent, Anxiety, Depression, Influencing factor