Abstract: Objective To explore the current situation of xerophthalmia among high school students in Xi‘an, and to analyze the related factors of xerophthalmia. Methods In 2021, students from 30 high schools in Xi’an were selected by multi-stage stratified sampling method as the research objects for the questionnaire survey and ophthalmological examination. The descriptive analysis method was used to analyze the prevalence of xerophthalmia among high school students, and univariate and multivariate analysis methods were used to analyze the influencing factors of xerophthalmia among high school students. Results A total of 521 high school students were included in the study, 312 were male, accounting for 59.88%; 209 were female, accounting for 40.12%; the average age was （16.28±1.98） years. Among them, 238 cases of xerophthalmia were detected, with a detection rate of 45.68%, including 176 cases of mild xerophthalmia, 52 cases of moderate xerophthalmia, and 10 cases of severe xerophthalmia, accounting for 73.95%, 21.85%, and 4.20% respectively. The results of unconditional Logistic stepwise regression analysis showed that grades （OR=2.389, 2.307）, wearing contact lenses or cosmetic contact lenses （OR=1.440）, myopia （OR=1.931）, using eye drops （OR=5.888）, receiving vision correction surgery （OR=2.210）, history of ocular trauma （OR=5.501）, frequency of electronic product use （OR=2.632, 4.669）, staying up late （OR=1.736, 1.887, 2.234）, and daily sleep time （OR=2.307, 2.704） were influencing factors of xerophthalmia in high school students. Conclusion The incidence of xerophthalmia among high school students in Xi ‘an is high. Wearing contact lenses or cosmetic contact lenses and a history of eye correction and so on are risk factors of xerophthalmia among high school students. It is suggested that schools should properly strengthen the popularization of students’ relevant knowledge and propaganda of protection measures to reduce the incidence of eye disease among high school students.

Key words: High school students, Xerophthalmia, Vision, ophthalmopathy, Influencing factor