Abstract: Objective To explore the compliance of liver cancer screening in high-risk population for liver cancer in the Anhui region, and analyze the related influencing factors, to provide a reference for formulating relevant management strategies. Methods Adult residents who participated in a physical examination in a hospital in Suzhou City from November 2020 to May 2022 and were assessed to be at high risk of liver cancer according to the results of the anti-cancer assessment were selected as the subjects for abdominal ultrasound examination and α-fetoprotein （AFP） detection. A self-made questionnaire was used to investigate the high-risk population for liver cancer. The screening status of the high-risk population for liver cancer was analyzed, and the influencing factors of screening compliance for the high-risk population for liver cancer were analyzed through univariate and multivariate analysis methods. Results Among the 802 high-risk individuals for liver cancer, 386 underwent subsequent liver cancer screening, with a participation rate of 48.13%. Multivariate Logistic regression analysis showed that age < 60 years old （OR=4.424）, Han nationality （OR=2.765）, alcohol consumption （OR=5.551）, chronic hepatitis （OR=4.250）, fatty liver （OR=5.140）, history of gallstones （OR=2.757）, and family history of liver cancer （OR=5.590） were independent influencing factors for compliance of liver cancer screening in high-risk population for liver cancer. Conclusions The participation compliance of liver cancer screening in the high-risk population for liver cancer in the Anhui region is not high. It is of great value to provide certain intervention measures for relevant influencing factors to improve screening compliance.

Key words: Physical examination, Liver cancer, High-risk population, Liver cancer screening, Compliance, Influencing factor