Abstract: Objective To investigate the factors affecting the occurrence and outcome of polypoid lesion of gallbladder. Methods The patients with polypoid lesion of gallbladder hospitalized in Quanjiao County People's Hospital were randomly selected as the case group. The patients without polypoid lesion of gallbladder who were hospitalized in the hospital treatment center at the same time were selected as the control group according to the principle of the same sex and age ±3 years old. The questionnaire survey included personal basic information, smoking and drinking, history, etc. Univariate and multivariate analysis methods were used to analyze the factors affecting the occurrence and outcome of polypoid lesion of gallbladder. Results There were 1 371 cases in the case group and the control group, respectively, with an average age of （57.69±6.89） years in the case group and （57.75±7.26） years in the control group. The ratio of male to female in both groups was 1:0.68. There were no significant differences in age and gender between the two groups （t=0.593, χ²=0.00, both P>0.05）. There were no significant differences in marital status, education level, and average monthly family income between the two groups （all P>0.05）. Among 1 371 patients with polypoid lesion of gallbladder, 852 patients had a good prognosis, with an average age of （53.47±6.84） years, and 519 patients had a poor prognosis, with an average age of （64.62±7.18） years. There was a statistically significant difference in age between the two groups （P<0.01）. Multivariate logistic regression analysis showed that Han nationality （OR=1.925）, overweight and obesity （OR=1.235）, hypertension （OR=2.614）, diabetes （OR=1.551）, gallstone （OR=1.473）, history of cholecystitis （OR=1.519）, and anti-HBc positive （OR=2.821） were independent risk factors for polypoid lesion of gallbladder. Age （OR=1.711）, male （OR=1.474）, overweight and obesity （OR=1.220）, diabetes （OR=1.560）, dyslipidemia （OR=2.620）, and anti-HBc positive （OR=3.001） were independent risk factors for the outcome of polypoid lesion of gallbladder. Conclusion Polypoid lesion of gallbladder is affected by ethnicity, body mass index, hypertension, diabetes, and anti-HBc, and there are significant differences in clinical outcomes among patients with different characteristics.

Key words: Polypoid lesion of gallbladder, Influencing factor, Case control, Case outcome