Abstract: Objective To investigate the prevalence of non-motor symptoms in patients with Parkinson's disease and to study its impact on quality of life. Methods The Parkinson's patients admitted to Beijing Tiantan Hospital from September 2020 to August 2023 were selected for this study. The general data such as age and gender of the patients were obtained. A series of scales such as Hamilton Depression Scale （HAMD）,Hamilton Anxiety Scale （HAMA）,and Parkinson's Disease Cognitive Function Rating Scale （PD-CRS） were used to evaluate the non-motor symptoms of the patients. The Parkinson's Disease Quality of Life Scale-39 （PDQ-39） was used to evaluate the quality of life of the patients. Spearman correlation analysis was used to analyze the correlation between PDQ-39 score and non-motor symptom scale scores. The influencing factors were analyzed by multiple linear regression model. Results As a result,1 215 Parkinson's patients were ultimately included in this study. The incidence of various non-motor symptoms was as follows：autonomic dysfunction 81.40%,pain 65.19%,sleep disorders 53.58%,fatigue 43.13%,depression 38.85%,anxiety 30.21%,cognitive dysfunction 24.20%,impulse control disorder 22.72%,and apathy 20.82%. The average PDQ-39 score of 1 215 patients was （43.52 ± 5.61） points. The results of multiple linear regression analysis showed that the HAMD score （β'=0.243）,HAMA score （β'=0.531）,PD-CRS score （β'=-0.287）,Parkinson's Disease Prognostic Scale Autonomic Nerve score （β'=0.781）,Pittsburgh Sleep Quality Index （β'=0.478）,and KING′s Parkinson's Disease Pain Scale score （β'=0.259） all had a significant impact on the quality of life of Parkinson's patients （all P<0.01）. Conclusions The incidence of non-motor symptoms such as autonomic dysfunction,pain,sleep disorders,anxiety,and depression in patients with Parkinson 's disease is high,and the more serious the above non-motor symptoms,the worse the quality of life of patients. It is necessary to find effective targeted non-motor symptoms interventions to comprehensively improve the quality of life of patients.

Key words: Parkinson's disease, Non-motor symptoms, Quality of life, Status survey