Abstract: Objective To investigate the trend of morbidity and mortality of thyroid cancer in Wuhan from 2010 to 2019, so as to provide a scientific basis for prevention and control. Methods Based on the incidence and mortality data of thyroid cancer between 2010 and 2019 in Wuhan mortality and chronic surveillance system. We analyzed the change trend of thyroid cancer in incidence, mortality, standardized mortality and standardized mortality among different gender and age-groups. A Joinpoint regression model was used to examine secular trends. Results From 2010 to 2019, the incidence of thyroid cancer in Wuhan was 33.75/10⁵. The incidence of thyroid cancer was 52.38/10⁵ in females which was much higher than that in males 15.66/10⁵, with statistical significance (P<0.05). The mortality rate of thyroid cancer was 0.4/10⁵ from 2010 to 2019. The mortality rate of thyroid cancer was 0.51/10⁵ in females which was much higher than that in males 0.29/10⁵, with statistical significance (P<0.05). Increasing trend were shown in incidence (AAPC was 21.674%, P<0.05) and standardized incidence (AAPC was 21.720%, P<0.05) of thyroid cancer in Wuhan from 2010 to 2019. There was no statistical significance in the trend of thyroid cancer mortality (AAPC was 4.891%, P>0.05) and standardized mortality (AAPC was 2.479%, P>0.05). The age curve of thyroid cancer incidence showed an unimodal distribution, and the peak of male incidence was 40-<45 years old, the incidence peaks in the 50-<55 age group in females. Conclusions From 2010 to 2019, the incidence and mortality of thyroid cancer in females in Wuhan was significantly higher than that in males, and the incidence increased with age increased, while the death rate did not increase significantly. Therefore, early screening of thyroid cancer should be actively carried out for menopausal women.

Key words: Thyroid cancer, Incidence, Mortality, Joinpoint regression model