Abstract: Objective To understand the cognition of COVID-19 vaccine among permanent residents in Liwan District of Guangzhou City, and to explore the vaccination willingness and its influencing factors, so as to provide basis for improving the vaccination rate of COVID-19. Methods From November 1 to December 15, 2020, permanent residents aged 18-59 years old in Liwan District of Guangzhou City were invited to fill in the questionnaire online through wjx.cn. The contents included basic information, cognition of COVID-19 vaccine and vaccination willingness. Descriptive epidemiological method was used to analyze the results, multivariate Logistic regression analysis method was used to analyze the influencing factors of vaccination willingness. Results A total of 5 763 permanent residents aged 18-59 years old were investigated, of which 23.58% were male and 76.42% were female. The willingness rate of COVID-19 vaccine was 82.44%. Multivariate Logistic regression analysis showed that the residents who were engaged in teaching profession （OR=3.009）, housework （OR=2.691）, medical staff （OR=2.652）, catering and food industry （OR=2.292）, and residents who believed that vaccine was safety （OR=24.007） and considered in a high risk of COVID-19 infectious （OR=17.528） were highly willing to get the vaccination. Conclusion The permanent residents aged 18-59 years old in Liwan District of Guangzhou City are more willing to be vaccinated with COVID-19 vaccine. The occupation, the cognition of vaccine safety and the cognition of COVID-19 are the factors that influence COVID-19 vaccination willingness among residents.

Key words: COVID-19, Vaccine, Vaccination, Influencing factor