Abstract: Objective To study the status and influencing factors of AIDS-related knowledge, attitude, and practice among college students in Xinyang City, so as to strengthen the education and publicity of AIDS among college students and enhance their self-protection ability. Methods In April 2021, a convenient sampling method was used to conduct a questionnaire survey on AIDS-related knowledge, attitude, and practice among college students in 3 colleges and universities in Xinyang City, and the results were analyzed by the descriptive analysis method. Univariate and multivariate analysis methods analyzed the influencing factors of AIDS-related knowledge, attitude, and practice scores. Results A total of 1 219 students were included in the survey. The average score for AIDS-related knowledge was （17.02±3.95）, for AIDS-related attitude was （86.71±9.20）, and for AIDS-related risky practice was （11.30±2.16）. Multiple linear regression analysis showed that grade （β'=2.014）, major （β'=-0.291）, origin （β'=0.109）, and history of sexual behavior （β'=0.765） were the influencing factors of AIDS-related knowledge scores among college students. Grade （β'=0.096）, major （β'=-0.180）, origin （β'=0.281）, history of sexual behavior （β'=0.369）, and AIDS-related knowledge score （β'=0.281） were the influencing factors of AIDS-related attitude scores among college students. Gender （β'=0.638）, grade （β'=0.142）, major （β'=-0.242）, origin （β'=-0.357）, history of sexual behavior （β'=-0.658）, history of urogenital diseases （β'=0.257）, AIDS-related knowledge score （β'=-0.276）, and AIDS-related attitude score （β'=-0.307） were the influencing factors of AIDS-related risky practice scores among college students. Conclusion The AIDS-related knowledge, attitude, and practice of college students in Xinyang City are affected by a variety of factors, and relevant health education measures should be strengthened to improve the level of AIDS-related knowledge and attitude of college students effectively and reduce the occurrence of risky practice, promote AIDS prevention and control.

Key words: AIDS, College students, Knowledge, attitude, and practice, Influencing factor