Abstract: Objective To analyze the status of thyroid nodules in physical examination population and explore its influencing factors, so as to provide reference for the publicity and education of healthy people. Methods The data collection and thyroid nodule examination were performed on the population of a hospital in Liaoyang City, Liaoning Province who underwent a physical examination from September 2018 to August 2020. The descriptive epidemiological analysis method was used to analyze, and single and multiple factor analysis methods were used to analyze the factors affecting the detection of thyroid nodules. Results A total of 22 557 healthy subjects in Liaoyang City were surveyed. Male accounted for 48.9% and female accounted for 51.1%. They were 19-76 years old, and the majority was 51-69 years old, accounting for 40.6%; the residential area was mainly urban, accounting for 63.1%. Thyroid nodules were detected in 1 258 cases, and the detection rate was 5.6%, of which 63.3% were single nodules and 65.6% were solid nodules. Multivariate Logistic regression analysis showed that female （OR=3.597）, older people （OR=5.789）, greater body mass index （OR=3.142）, depression （OR=8.117）, anxiety （OR=7.591）, abnormal blood pressure （OR=3.124）, abnormal blood glucose （OR=3.337） in healthy subjects had higher risk of thyroid nodules. Conclusion The detection rate of thyroid nodules in physical examination population in Liaoyang City is relatively high, and single and solid nodules are more common. The incidence is affected by gender, age, weight, mental state, blood pressure, and blood glucose. Early prevention and treatment measures of thyroid nodule should be strengthened.

Key words: Physical examination, Thyroid nodules, Detection rate, Influencing factor