Abstract: Objective To explore the status of secondary prophylactic medication in patients with ischemic cardiocerebrovascular disease, and to analyze the related factors affecting medication compliance. Methods Patients with ischemic cardiocerebrovascular disease who received treatment in a hospital in Zhengzhou from January 2021 to January 2022 were included to conduct a questionnaire survey on secondary prophylactic medication, and results of medication type and compliance were analyzed by descriptive analysis method. The factors influencing the compliance of secondary prophylactic medication in this population were analyzed by univariate and multivariate analysis methods. Results A total of 763 patients with ischemic cardiocerebrovascular disease were investigated in this study, and 750 patients were effectively investigated, the effective rate was 98.29%. Among them, 306 patients with ischemic heart disease, 422 patients with ischemic stroke, and 22 patients complicated with ischemic heart disease and ischemic stroke. Of the 750 patients with ischemic cardiocerebrovascular disease, 198 cases reported taking antiplatelet drugs or statins, accounting for 26.40%. The proportion of patients taking antiplatelet drugs only and statins only was 45.95% （91/198） and 29.29% （58/198）, respectively. There were 112 patients with good medication compliance, and the compliance rate was 56.57%. Binary Logistic regression analysis showed that gender （OR=2.289）, age （OR=0.624）, an education level （OR=2.020）, work status （OR=3.391）, annual family income （OR=1.723, 2.164）, complicated with hypertension （OR=1.266）, and course of disease （OR=0.531, 0.267） were related factors affecting compliance of secondary prophylactic medication in patients with ischemic cardiocerebrovascular disease. Conclusions The rate of secondary prophylaxis medication was low in patients with ischemic cardiocerebrovascular disease in Zhengzhou, and the compliance was poor, among which the gender, age, education level, annual family income, work status, and course of disease were all important factors affecting the medication compliance.

Key words: Ischemic cardiocerebrovascular disease, Ischemic stroke, Ischemic heart disease, Secondary prophylaxis, Medication compliance