Abstract: Objective To investigate the detection status of non-alcoholic fatty liver disease （NAFLD） and related risk factors in the adult health examination population in Shanghai. Methods Adults who underwent physical examination in Huadong Sanatorium from January to December 2020 were selected as the research objects, and their basic data and physical examination results were collected. The Logistic regression model was used to analyze the possible risk factors of NAFLD. Results A total of 14 346 healthy people were included, including 7 623 males and 6 723 females, aged 18-90 years, with an average of （46.04 ± 11.97） years. A total of 5 567 cases of NAFLD were detected, with a detection rate of 38.8%. Multivariate Logistic regression analysis showed that females were at less risk of NAFLD than males （OR=0.623）. The risk of NAFLD was higher in those with each increase of 1 year in age （OR=1.036）, central obesity （OR=1.403）, a meat-based diet or a diet high in sugar and salt （OR=1.713）, dyslipidemia （OR=3.433）, high fasting glucose （OR=3.664）, abnormal liver function （OR=4.403）, hypertension （OR=1.936）, and high uric acid （OR=2.712）. Conclusion The detection rate of NAFLD in adult health examination population in Shanghai is high. Male, age increase, central obesity, a meat-based diet or a diet high in sugar and salt, abnormal liver function, high fasting glucose, dyslipidemia, high uric acid, and hypertension are the risk factors for NAFLD.

Key words: Non-alcoholic fatty liver disease, Obesity, Metabolic abnormality, Health examination population, Risk factor