Abstract: Objective To analyze the care needs of HIV/AIDS on AIDS-related health information, emotional support, and health care assurance to provide the basis for the development of HIV/AIDS care and support policies. Methods A self-designed questionnaire was used to investigate individuals living with HIV/AIDS who could be tracked in Zhuhai. The survey contents included demographic information, route of infection, detection and treatment, and demands for HIV/AIDS-related health information, emotional support, and medical insurance. Results A total of 436 HIV/AIDS cases were investigated and their average age was （36.9±10.7）years. Among all the cases, 75.0% were male, 36.7% had educational level at the junior middle school, 68.8% had average monthly gross income ≤3 000 Yuan, and 74.8% were incumbent; 44.0% were infected through heterosexual transmission, 75.7% had accepted the antiretroviral therapy, 40.1% had a better understanding of HIV/AIDS prevention knowledge, 20.4% had the knowledge of psychological decompression, 19.3% knew the knowledge of HIV/AIDS treatment and medicines, 15.8% understood nutrition knowledge, 13.1% knew about social medical insurance policy; 49.5% obtained related information through consulting physicians and 38.1% through visiting the internet, and there were significant differences in the ways to obtain the information for HIV/AIDS cases in different routes of infection and different residence (P<0.01 for all); 59.9% hoped to get the support from their families, and the proportions that the cases could get family support were different from different routes of transmission (P<0.01); 68.6% participated in social medical insurance, and the percentage that the quality of life was negatively affected in persons who participated in social medical insurance was lower than that in cases who did not (36.5% ［109/299］ vs. 48.2% ［66/137］; P<0.01). Conclusion People living with HIV/AIDS knew less about the HIV/AIDS-related health information and many factors influenced their care demands for HIV/AIDS-related health information, emotional support, and health care assurance. Care service should be provided for them based on the demands assessment.