Abstract: Objective To analyze the incidence of chronic kidney disease （CKD） in population at high risk of CKD, so as to provide reference data for improving the prevention and control of CKD. Methods The high-risk population of CKD publicly recruited by a third-class hospital in Chengdu from April to September 2019 was taken as the research object, basic information collection, blood biochemical index and renal function index examination were carried out. The occurrence of CKD was analyzed by descriptive epidemiological analysis method, and its influencing factors were analyzed by univariate and multivariate analysis. Results A total of 7 384 high-risk population of CKD were included, including 3 910 males and 3 474 females, aged 29 - 74 years, mainly 60 - 74 years old, accounting for 42.5%. Among them, there were 2 872 cases of hypertension, 1 760 cases of hyperuricemia, 1 929 cases of diabetes mellitus, 1 035 cases of family history of chronic nephritis, and 627 cases of family history of hereditary renal disease. There were 3 190 cases with one kind of high-risk factors, 2 836 cases with two kinds, and 1 358 cases with three or more kinds. A total of 796 cases of CKD were diagnosed, and the detection rate was 10.8%. The main disease stage was G2, accounting for 52.5%, and the risk stratification was mainly low-risk, accounting for 51.1%. Multivariate Logistic regression analysis showed that the risk of CKD was higher among high-risk population of CKD who were women （OR=1.441）, older age （OR=1.244）, with hypertension （OR=2.375）, hyperuricemia （OR=2.617）, diabetes mellitus （OR=1.818）, a family history of chronic nephritis （OR=3.476）, and two kinds （OR=1.442） or three or more kinds of high-risk factors （OR=1.514）. Conclusion The detection rate of CKD in high-risk population of CKD is relatively high. The staging of CKD is mainly G2 stage and low-risk. For high-risk population of CKD who are women, advanced age, hypertension, and with multiple risk factors should focus on screening. Early prevention, detection and treatment of CKD can reduce the harm of disease to patients.

Key words: Chronic kidney disease, High-risk population, Screening, Glomerular filtration rate