Abstract: Objective To screen the permanent residents aged ≥40 years in Huangpu District, Guangzhou to understand the exposure of stroke risk factors, identify the high-risk population, and provide scientific basis for the prevention and control of stroke. Methods Convenient sampling method was used to select five communities in Huangpu District, Guangzhou from June to December in 2019. Questionnaire survey, physical examination and laboratory tests were carried out on the respondents.Using a simple comprehensive risk assessment tool for cardiovascular diseases, the 10-year absolute risk of ischemic cardiovascular and cerebrovascular disease （ICVD） in the identified high-risk population of stroke was calculated. Results A total of 802 people were effectively investigated, including 371 males and 431 females, aged 40 - 92 years, with an average age of （55.20±11.10） years. Most of them were married, accounting for 90.15%. The education level was evenly distributed, and the employees in enterprises and public institutions accounted for the highest proportion （48.88%）. A total of 195 people with high risk of stroke were screened （the detection rate was 24.31%）, and the detection rate of male （34.50%） was higher than that of female （15.55%） （P<0.01）.The 10-year absolute risk of ICVD in the high-risk population of stroke was4.76%.Among the high-risk population of stroke, the top five risk factors of exposure were hypertension（76.92%）, hyperlipidemia（64.10%）, less exercise（61.54%）, smoking（43.08%）, and diabetes（33.33%）. Conclusion In Huangpu District, Guangzhou, the detection rate of high-risk population of stroke in permanent residents aged ≥40 years is high. Therefore, screening should be popularized, and comprehensive intervention measures such as health management and education should be adopted to reduce the incidence of stroke.

Key words: Stroke, Screening, High risk population, Risk factor