Abstract: Objective To study the detection and influencing factors of Helicobacter pylori in patients with chronic gastritis, and to provide the reference for prevention of Helicobacter pylori-related chronic gastritis. Methods Patients with chronic gastritis diagnosed and treated at the People's Hospital of Tunchang County and the First Affiliated Hospital of Hainan Medical College from January to December 2021 were selected. The ¹³C-urea breath test was used to detect Helicobacter pylori. Demographic information and behaviors related to digestive disorders of the patients were collected, and the detection of Helicobacter pylori in patients with chronic gastritis was analyzed by descriptive analysis. The influencing factors of Helicobacter pylori infection in patients with chronic gastritis were analyzed by univariate and multivariate analysis methods. Results Among the 1 126 patients with chronic gastritis, there were 589 males and 537 females, aged 26-73 years old, with the proportion of 50-59 years old accounting for 36.86%; there were 491 cases in rural areas and 635 cases in urban areas. The course of disease was higher in 6-12 months, accounting for 57.29%. A total of 421 cases tested positive for Helicobacter pylori, with a positive rate of 37.39%. Multivariate Logistic regression analysis showed that age （OR=2.115）, family history of infection （OR=3.600）, course of disease （OR=1.507）, drinking habit （OR=1.988）, and cognitive level of Helicobacter pylori （OR=0.614） were influencing factors of Helicobacter pylori infection in patients with chronic gastritis. Conclusions The detection rate of Helicobacter pylori infection in patients with chronic gastritis is high and the status of the infection is not optimistic, which is affected by various factors. Prevention and treatment should be strengthened according to various factors, and infection screening should be strengthened to reduce the risk of infection.

Key words: Helicobacter pylori, Chronic gastritis, ¹³C-urea breath test, Influencing factor