Abstract: Objective To investigate the status of emergency response ability for major infectious diseases among medical staff in Xi'an, and analyze the relevant factors affecting emergency response ability, in order to provide the reference for the development of targeted epidemic emergency management measures. Methods In March 2022, the stratified cluster sampling method was used to select medical staff from some medical institutions in Xi'an for this study, and the “Wenjuanxing” network survey was used to investigate the emergency response ability of medical staff for major infectious diseases. Results The total score of emergency response ability of 1 056 medical staff was （120.83±11.69） points, with an average score of （3.18±0.63） points for the total items, and a total score rate of 63.61%.Among them, 83.14% of medical staff had a medium to low level of emergency response ability. The scoring rates of various dimensions of emergency response ability from high to low were prevention ability （65.41%）, rescue ability （64.37%）, and preparedness ability （59.18%）.Multiple linear regression analysis showed that the hospital level was second grade A （β'=- 0.316）, professional title （senior） （β'= 0.374）, specialty type （preventive medicine） （β'= 0.635）, working years （β'= 0.283）, and whether they had participated in emergency training （β'= 1.017）, emergency drills （β'= 1.561）, and rescue of infectious disease emergencies （β'= 1.985） were the main influencing factors of emergency response ability among medical staff for major infectious diseases. In addition, 30.9% of the variation could be explained by hospital level, professional title, specialty type, working years, and participation in emergency training/drills and emergency rescue of infectious diseases. Conclusions The overall emergency response ability of medical staff in Xi'an for major infectious diseases is relatively low. It is necessary to focus on strengthening the rescue drills and training for medical staff with lower qualifications and professional titles in hospitals, in order to further improve their emergency response ability for major infectious diseases.

Key words: Medical staff, Infectious diseases, Epidemic situation, Emergency ability