Abstract: Objective To analyze the current status of polypoid lesion of gallbladder （PLG） and related risk factors in physical examination population in Shanghai. Methods From January 1 to December 31, 2021, the participants who underwent physical examination in East China Sanatorium were selected to collect their basic information and physical examination results. The PLG were examined by ultrasonography, and the related factors were analyzed by univariate and multivariate analysis methods. Results There were 4 902 healthy subjects, including 2 967 males, with an average age of （46.64±10.06） years. A total of 1 008 cases of PLG were detected, the total detection rate was 20.6%. Multivariate logistic regression analysis showed that female （OR=0.703）, bachelor degree or below （OR=0.667）, married （OR=0.028）, smoking （OR=1.350）, drinking （OR=22.270）, drinking milk frequently （OR=1.283）, Hp positive （OR=84.330）, frequent mental stress （OR=1.245）, and central obesity （OR=1.327） were associated with PLG. Conclusions The detection rate of PLG is relatively high in the health examination population in Shanghai. Males, smokers, drinkers, frequent mental stress, central obesity, HP positive individuals, and those who frequently drink milk have a higher risk of PLG.

Key words: Polypoid lesion of gallbladder, Risk factor, Physical examination population