Abstract: Objective To investigate the correlation between e-health literacy and drug compliance in young and middle-aged patients with hypertension. Methods A questionnaire survey was conducted on young and middle-aged hypertensive patients who were treated in the outpatient clinic of a hospital in Henan Province from January to December 2019 to investigate the e-health literacy and drug compliance, and the correlation between them was analyzed. Results In 384 young and middle-aged patients with hypertension, the average score of drug compliance was （3.67 ± 1.51）, the total average score of e-health literacy was （16.90 ± 4.86）, and there was a positive correlation between e-health literacy and drug compliance of young and middle-aged patients with hypertension （r=0.529, P<0.05）. Multiple linear regression analysis showed that the better the e-health literacy （β'=0.139）, the older （β'=0.104）, the higher the education level （β'=0.126）, and the longer the medication period （β'=0.103）, the better the drug compliance of the young and middle-aged hypertensive patients. The drug compliance of the young and middle-aged hypertensive patients with adverse drug reactions （β'=-0.109） was worse. Conclusion The e-health literacy and drug compliance of young and middle-aged patients with hypertension need to be improved. Clinical medical staff should pay attention to it. Improving the level of e-health literacy is helpful to improve the drug compliance of patients.

Key words: Young and middle-aged, Hypertension, E-health literacy, Drug compliance, Correlation