Abstract: Objective To investigate the compliance of screening among high-risk individuals of liver cancer ≥ 40 years old in Xi'an, and explore its influencing factors. Methods The residents ≥ 40 years old and living in Xi'an for ≥ 3 years were selected by convenient sampling method to participate in the evaluation of high risk for liver cancer, and the residents who were assessed as high risk of liver cancer were tested for blood alpha-fetoprotein and abdominal ultrasound, and the results of screening, compliance with screening, and its influencing factors were analyzed by descriptive analysis method and multivariate analysis method. Results In this study, 36 187 residents in Xi'an City were screened for high risk of liver cancer, of which 6 514 residents were assessed as high risk of liver cancer, and the high-risk rate was 18.00%. Among them, the proportion of male high-risk persons was higher than that of females, 99.08% were Han nationality, 96.65% were married, and the risk of liver cancer was higher in people ≥ 60 years old, most of whom had junior high school education or above, 88.12% had a body mass index （BMI） value of 18.5-27.9 kg/m2, 58.40% had a history of smoking, 43.71% had a habit of drinking, 44.00% had a family history of tumor, 71.17% had a history of chronic hepatitis C, and 97.19% had a history of chronic hepatitis B. Among 6 514 high-risk individuals of liver cancer, 3 192 cases participated in liver cancer screening, and the compliance of screening was 49.00%. Multivariate Logistic regression analysis showed that age （OR＝0.444）, BMI （OR＝0.694,0.820）, smoking （OR＝1.177）, alcohol consumption （OR＝1.178）, chronic hepatitis B （OR＝1.266）, family history of tumor （OR＝1.579）, occupation （OR＝4.204）, times of exercise （OR＝0.774）, average monthly household income （OR＝1.790）, and regular examination （OR＝2.542） were the influencing factors of screening compliance. Conclusions The screening compliance of high-risk individuals of liver cancer in Xi'an is generally low, and many important factors affect screening compliance. We can further improve the screening mechanism and improve the screening efficiency by strengthening health education and strengthening communication between doctors, nurses, and patients.

Key words: High-risk individuals of liver cancer, Screening compliance, Status survey, Influencing factor