Abstract: Objective To investigate the prevalence and influencing factors of non-alcoholic fatty liver disease （NAFLD） in overweight and obese persons. Methods Overweight and obese people who completed a physical examination in a hospital in Xi'an in 2021 were selected. Their basic information, physiological and biochemical information, and diagnosis results of abdominal color doppler ultrasonography were collected. The descriptive method was used to analyze the prevalence of NAFLD in overweight and obese persons, and univariate and multivariate analysis methods were used to analyze the influencing factors of NAFLD. Results A total of 6 351 overweight and obese persons were obtained from 12 964 physical examiners, including 3 325 males （52.35%） and 3 026 females （47.65%）. The age was 33-76 years old, and the proportion of 60-76 years old was higher, accounting for 37.40%. A total of 1 222 cases were diagnosed as NAFLD, with a prevalence rate of 19.24%. Among them, 365 cases were mild （29.87%）, 778 cases were moderate （63.67%）, and 79 cases were severe （6.46%）. Multivariate Logistic regression analysis showed that males （OR＝2.807）, aged 44 and over （OR＝3.684, 4.158）, obesity （OR＝2.177）, abnormally high SBP （OR＝4.745）, abnormal waist circumference （OR＝3.102）, abnormal ALT （OR＝2.740）, abnormal AST （OR＝2.726）, abnormal GGT （OR＝2.373）, abnormal FBG （OR＝3.684）, abnormal UA （OR＝3.096）, abnormal TG （OR＝3.490）, abnormal TC （OR＝3.819）, abnormal LDL-C （OR＝3.647）and abnormal HDL-C（OR＝2.807） were risk factors of NAFLD in overweight and obese persons. Conclusions The prevalence of NAFLD in overweight and obese persons in a physical examination population is high, so targeted intervention is needed as soon as possible. Some factors are identified as the influencing factors of NAFLD in this population, which is helpful to guide the implementation of the intervention.

Key words: Physical examination population, Overweight, Obesity, Non-alcoholic fatty liver disease, Cirrhosis