Abstract: Objective To analyze the traffic injury disease burden of registered residents in Guangdong Province from 2005 to 2015, and to provide scientific basis for the development of traffic injury prevention and control strategies. Methods The traffic injury mortality, standardized mortality, years of life lost （YLL） due to early death, years lost due to disability （YLD）, disability adjusted life year （DALY）, life expectancy, and life expectancy regardless of death cause were calculated using the monitoring data of traffic injury causes of death of registered residents in Guangdong Province from 2005 to 2015. Percentage of annual change （APC） was used to describe the change trend of the above indexes. Results The mortality rate of traffic injury among registered residents in Guangdong Province decreased from 20.20/100 000 in 2005 to 11.89/100 000 in 2015 （APC=-5.45%,P<0.01）. The mortality rate of male traffic injury was higher than that of female （all P<0.05）. From 2005 to 2015, the YLL rate and DALY rate of traffic injury showed a decreasing trend （APC=-6.95%,-5.92%,both P<0.01）, while the YLD rate showed an increasing trend （APC=2.43%,P<0.01）. In 2005, the DALY rate of traffic injury among people over 20 years old decreased with the increase of age; In 2015, the DALY rate of traffic injury increased with the increase of age, and the DALY rate of traffic injury among people aged 5-60 years old decreased compared with that in 2005, and the biggest decrease （68%） was in the group of 25-29 years old, while the burden of the group of 50-70 years old was higher, maintain at a high level. The life added value after the elimination of traffic injury decreased from 0.52 years in 2005 to 0.32 years in 2015 （P>0.05）. Conclusions Traffic injury has become the main accidental injury cause of death of registered residents in Guangdong Province. Males and people over 50 years old should be taken as the key groups for traffic injury intervention.

Key words: Traffic injury, Mortality, Disease burden, Life expectancy