Abstract: Objective To explorethe awareness of core knowledge on cancer prevention and treatment in high-risk population of lung cancer, and analyze its influencing factors. Methods A survey was carried out on the core knowledge of cancer prevention and treatment among residents who were screened and identified as high-risk lung cancer group after physical examination in a thoracic surgery of a hospital in Shanghai from March 2017 to December 2019.Descriptive epidemiological analysis was used to analyze the core knowledge mastery of cancer prevention and treatment, and univariate and multivariate analysis methods were used to analyze the factors affecting knowledge mastery. Results A total of 416 cases with high risk of lung cancer aged 40-72 years were included, including 269 males and 147 females, accounting for 64.66% and 35.34%, respectively. The core knowledge of cancer prevention and treatment was known in 326 cases, and the awareness rate was 78.4%.The highest awareness rates were 92.79%, 92.31%, 90.38%, respectively, on the following three topics： “Physical examination or cancer screening is conducive to early detection of cancer”, “Cancer is not infectious;The early stage of cancer may have no obvious symptoms;Cancer examination is not the higher the price, the better the effect ”, “Smoking cessation is conducive to the prevention of lung cancer”. The lowest awareness rates were 50.24%, 37.98% and 34.86%, respectively, on the following three topics： “Give birth at proper age, breastfeeding, more physical activity, proper weight, less alcohol consumption and regular physical examination are beneficial to the prevention of breast cancer”, “Effective methods for early screening of lung cancer” and “High risk factors leading to the development of cancer”. Binary Logistic regression analysis showed that aged 60-72 years （OR=0.418）, education level of junior college or above （OR=2.309）, occupation type of health care industry （OR=4.121） werethe influencing factors of core knowledge of cancer prevention and treatmentin high-risk population of lung cancer. Conclusion The overall knowledge of cancer prevention and treatment among the high-risk group of lung cancer is better, but it should also be aimed at the older age, lower education level and people in the non-medical and health industries to further enhance cancer prevention and treatment awareness, and continuously improve the knowledge level of cancer prevention perception among the general population.

Key words: Lung cancer, High-risk population, Cancer prevention and treatment, Awareness rate, Tobacco control